Cancer Therapy: Clinical Mutated BCR-ABL Generates Immunogenic T-cell Epitopes in CML Patients
نویسندگان
چکیده
Purpose:Characterization of an approach to identify leukemia neoantigens arising in the context of drug
منابع مشابه
Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients.
PURPOSE Characterization of an approach to identify leukemia neoantigens arising in the context of drug resistance. EXPERIMENTAL DESIGN We assessed whether leukemia neoantigens could be generated from drug-resistant mutations in BCR-ABL after imatinib relapse in patients with chronic myelogenous leukemia (CML). RESULTS We computationally predicted that approximately 70 peptides derived from...
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تاریخ انتشار 2012